                         SEQUENCE LISTING

<110>  THE MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND 
       PUBLIC HEALTH LTD
 
<120>  DIAGNOSTIC, PROGNOSTIC, THERAPEUTIC AND SCREENING PROTOCOLS WITH 
       RESPECT TO INFECTIOUS MYCOBACTERIUM

<130>  35209829/JEH

<150>  AU 2012904886
<151>  2012-11-08

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  1920
<212>  DNA
<213>  Homo sapiens

<400>  1
atgctgctct tcgtgctcac ctgcctgctg gcggtcttcc cagccatctc cacgaagagt       60

cccatatttg gtcccgagga ggtgaatagt gtggaaggta actcagtgtc catcacgtgc      120

tactacccac ccacctctgt caaccggcac acccggaagt actggtgccg gcagggagct      180

agaggtggct gcataaccct catctcctcg gagggctacg tctccagcaa atatgcaggc      240

agggctaacc tcaccaactt cccggagaac ggcacatttg tggtgaacat tgcccagctg      300

agccaggatg actccgggcg ctacaagtgt ggcctgggca tcaatagccg aggcctgtcc      360

tttgatgtca gcctggaggt cagccagggt cctgggctcc taaatgacac taaagtctac      420

acagtggacc tgggcagaac ggtgaccatc aactgccctt tcaagactga gaatgctcaa      480

aagaggaagt ccttgtacaa gcagataggc ctgtaccctg tgctggtcat cgactccagt      540

ggttatgtaa atcccaacta tacaggaaga atacgccttg atattcaggg tactggccag      600

ttactgttca gcgttgtcat caaccaactc aggctcagcg atgctgggca gtatctctgc      660

caggctgggg atgattccaa tagtaataag aagaatgctg acctccaagt gctaaagccc      720

gagcccgagc tggtttatga agacctgagg ggctcagtga ccttccactg tgccctgggc      780

cctgaggtgg caaacgtggc caaatttctg tgccgacaga gcagtgggga aaactgtgac      840

gtggtcgtca acaccctggg gaagagggcc ccagcctttg agggcaggat cctgctcaac      900

ccccaggaca aggatggctc attcagtgtg gtgatcacag gcctgaggaa ggaggatgca      960

gggcgctacc tgtgtggagc ccattcggat ggtcagctgc aggaaggctc gcctatccag     1020

gcctggcaac tcttcgtcaa tgaggagtcc acgattcccc gcagccccac tgtggtgaag     1080

ggggtggcag gaggctctgt ggccgtgctc tgcccctaca accgtaagga aagcaaaagc     1140

atcaagtact ggtgtctctg ggaaggggcc cagaatggcc gctgccccct gctggtggac     1200

agcgaggggt gggttaaggc ccagtacgag ggccgcctct ccctgctgga ggagccaggc     1260

aacggcacct tcactgtcat cctcaaccag ctcaccagcc gggacgccgg cttctactgg     1320

tgtctgacca acggcgatac tctctggagg accaccgtgg agatcaagat tatcgaagga     1380

gaaccaaacc tcaaggtacc agggaatgtc acggctgtgc tgggagagac tctcaaggtc     1440

ccctgtcact ttccatgcaa attctcctcg tacgagaaat actggtgcaa gtggaataac     1500

acgggctgcc aggccctgcc cagccaagac gaaggcccca gcaaggcctt cgtgaactgt     1560

gacgagaaca gccggcttgt ctccctgacc ctgaacctgg tgaccagggc tgatgagggc     1620

tggtactggt gtggagtgaa gcagggccac ttctatggag agactgcagc cgtctatgtg     1680

gcagttgaag agaggaaggc agcggggtcc cgcgatgtca gcctagcgaa ggcagacgct     1740

gctcctgatg agaaggtgct agactctggt tttcgggaga ttgagaacaa agccattcag     1800

gatcccaggc tttttgcaga ggaaaaggcg gtggcagata caagagatca agccgatggg     1860

agcagagcat ctgtggattc cggcagctct gaggaacaag gtggaagctc cagaaggtga     1920


<210>  2
<211>  639
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      


Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          


Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              


Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  


Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  


Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      


Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         


Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             


Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 


Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 


Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     


Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         


Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             


Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 


Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 


Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     


Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         


Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             


Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 


Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 


Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     


Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         


Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             


Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 


Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 


Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     


Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         


Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             


Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 


Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 


Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     


Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         


Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             


Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 


Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 


Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     


Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         


Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             


Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 


Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Arg 
625                 630                 635                 


<210>  3
<211>  1947
<212>  DNA
<213>  RABBIT

<400>  3
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga gcctgatgac      420

gttgtttaca aacaatatga gagttataca gtaaccatca cctgcccttt cacatatgcg      480

actaggcaac taaagaagtc cttttacaag gtggaagacg gggaacttgt actcatcatt      540

gattccagca gtaaggaggc aaaggacccc aggtataagg gcagaataac gttgcagatc      600

caaagtacca cagcaaaaga attcacagtc accatcaagc atttgcagct caatgatgct      660

gggcagtatg tctgccagag tggaagcgac cccactgctg aagaacagaa cgttgacctc      720

cgactgctaa ctcctggtct gctctatgga aacctggggg gctcggtgac ctttgaatgt      780

gccctggact ctgaagacgc aaacgcggta gcatccttgc gccaggttag gggtggcaat      840

gtggtcattg acagccaggg gacaatagat ccagccttcg agggcaggat cctgttcacc      900

aaggctgaga acggccactt cagtgtagtg atcgcaggcc tgaggaagga agacacaggg      960

aactatctgt gcggagtcca gtccaatggt cagtctgggg atgggcccac ccagcttcgg     1020

caactcttcg tcaatgaaga gatcgacgtg tcccgcagcc cccctgtgtt gaagggcttt     1080

ccaggaggct ccgtgaccat acgctgcccc tacaacccga agagaagcga cagccacctg     1140

cagctgtatc tctgggaagg gagtcaaacc cgccatctgc tggtggacag cggcgagggg     1200

ctggttcaga aagactacac aggcaggctg gccctgttcg aagagcctgg caatggcacc     1260

ttctcagtcg tcctcaacca gctcactgcc gaggatgaag gcttctactg gtgtgtcagc     1320

gatgacgatg agtccctgac gacttcggtg aagctccaga tcgttgacgg agaaccaagc     1380

cccacgatcg acaagttcac tgctgtgcag ggagagcctg ttgagatcac ctgccacttc     1440

ccatgcaaat acttctcctc cgagaagtac tggtgcaagt ggaatgacca tggctgcgag     1500

gacctgccca ctaagctcag ctccagcggc gaccttgtga aatgcaacaa caacctggtc     1560

ctcaccctga ccttggactc ggtcagcgaa gatgacgagg gctggtactg gtgtggcgcg     1620

aaagacgggc acgagtttga agaggttgcg gccgtcaggg tggagctgac agagccagcc     1680

aaggtagctg tcgagccagc caaggtacct gtcgacccag ccaaggcagc ccccgcgcct     1740

gctgaggaga aggccaaggc gcggtgccca gtgcccagga gaaggcagtg gtacccattg     1800

tcaaggaagc tgagaacaag ttgtccagaa cctcggctcc ttgcggagga ggtagcagtg     1860

cagagtgcgg aagacccagc cagtgggagc agagcgtctg tggatgccag cagtgcttcg     1920

ggacaaagcg ggagtgccaa aaggtga                                         1947


<210>  4
<211>  648
<212>  PRT
<213>  RABBIT

<400>  4

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu Pro Asp Asp Val Val Tyr Lys 
    130                 135                 140                 


Gln Tyr Glu Ser Tyr Thr Val Thr Ile Thr Cys Pro Phe Thr Tyr Ala 
145                 150                 155                 160 


Thr Arg Gln Leu Lys Lys Ser Phe Tyr Lys Val Glu Asp Gly Glu Leu 
                165                 170                 175     


Val Leu Ile Ile Asp Ser Ser Ser Lys Glu Ala Lys Asp Pro Arg Tyr 
            180                 185                 190         


Lys Gly Arg Ile Thr Leu Gln Ile Gln Ser Thr Thr Ala Lys Glu Phe 
        195                 200                 205             


Thr Val Thr Ile Lys His Leu Gln Leu Asn Asp Ala Gly Gln Tyr Val 
    210                 215                 220                 


Cys Gln Ser Gly Ser Asp Pro Thr Ala Glu Glu Gln Asn Val Asp Leu 
225                 230                 235                 240 


Arg Leu Leu Thr Pro Gly Leu Leu Tyr Gly Asn Leu Gly Gly Ser Val 
                245                 250                 255     


Thr Phe Glu Cys Ala Leu Asp Ser Glu Asp Ala Asn Ala Val Ala Ser 
            260                 265                 270         


Leu Arg Gln Val Arg Gly Gly Asn Val Val Ile Asp Ser Gln Gly Thr 
        275                 280                 285             


Ile Asp Pro Ala Phe Glu Gly Arg Ile Leu Phe Thr Lys Ala Glu Asn 
    290                 295                 300                 


Gly His Phe Ser Val Val Ile Ala Gly Leu Arg Lys Glu Asp Thr Gly 
305                 310                 315                 320 


Asn Tyr Leu Cys Gly Val Gln Ser Asn Gly Gln Ser Gly Asp Gly Pro 
                325                 330                 335     


Thr Gln Leu Arg Gln Leu Phe Val Asn Glu Glu Ile Asp Val Ser Arg 
            340                 345                 350         


Ser Pro Pro Val Leu Lys Gly Phe Pro Gly Gly Ser Val Thr Ile Arg 
        355                 360                 365             


Cys Pro Tyr Asn Pro Lys Arg Ser Asp Ser His Leu Gln Leu Tyr Leu 
    370                 375                 380                 


Trp Glu Gly Ser Gln Thr Arg His Leu Leu Val Asp Ser Gly Glu Gly 
385                 390                 395                 400 


Leu Val Gln Lys Asp Tyr Thr Gly Arg Leu Ala Leu Phe Glu Glu Pro 
                405                 410                 415     


Gly Asn Gly Thr Phe Ser Val Val Leu Asn Gln Leu Thr Ala Glu Asp 
            420                 425                 430         


Glu Gly Phe Tyr Trp Cys Val Ser Asp Asp Asp Glu Ser Leu Thr Thr 
        435                 440                 445             


Ser Val Lys Leu Gln Ile Val Asp Gly Glu Pro Ser Pro Thr Ile Asp 
    450                 455                 460                 


Lys Phe Thr Ala Val Gln Gly Glu Pro Val Glu Ile Thr Cys His Phe 
465                 470                 475                 480 


Pro Cys Lys Tyr Phe Ser Ser Glu Lys Tyr Trp Cys Lys Trp Asn Asp 
                485                 490                 495     


His Gly Cys Glu Asp Leu Pro Thr Lys Leu Ser Ser Ser Gly Asp Leu 
            500                 505                 510         


Val Lys Cys Asn Asn Asn Leu Val Leu Thr Leu Thr Leu Asp Ser Val 
        515                 520                 525             


Ser Glu Asp Asp Glu Gly Trp Tyr Trp Cys Gly Ala Lys Asp Gly His 
    530                 535                 540                 


Glu Phe Glu Glu Val Ala Ala Val Arg Val Glu Leu Thr Glu Pro Ala 
545                 550                 555                 560 


Lys Val Ala Val Glu Pro Ala Lys Val Pro Val Asp Pro Ala Lys Ala 
                565                 570                 575     


Ala Pro Ala Pro Ala Glu Glu Lys Ala Lys Ala Arg Cys Pro Val Pro 
            580                 585                 590         


Arg Arg Arg Gln Trp Tyr Pro Leu Ser Arg Lys Leu Arg Thr Ser Cys 
        595                 600                 605             


Pro Glu Pro Arg Leu Leu Ala Glu Glu Val Ala Val Gln Ser Ala Glu 
    610                 615                 620                 


Asp Pro Ala Ser Gly Ser Arg Ala Ser Val Asp Ala Ser Ser Ala Ser 
625                 630                 635                 640 


Gly Gln Ser Gly Ser Ala Lys Arg 
                645             


<210>  5
<211>  1935
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  5
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga gctcctaaat      420

gacactaaag tctacacagt ggacctgggc agaacggtga ccatcaactg ccctttcaag      480

actgagaatg ctcaaaagag gaagtccttg tacaagcaga taggcctgta ccctgtgctg      540

gtcatcgact ccagtggtta tgtaaatccc aactatacag gaagaatacg ccttgatatt      600

cagggtactg gccagttact gttcagcgtt gtcatcaacc aactcaggct cagcgatgct      660

gggcagtatc tctgccaggc tggggatgat tccaatagta ataagaagaa tgctgacctc      720

caagtgctaa agcccgagcc cgagctggtt tatgaagacc tgaggggctc agtgaccttc      780

cactgtgccc tgggccctga ggtggcaaac gtggccaaat ttctgtgccg acagagcagt      840

ggggaaaact gtgacgtggt cgtcaacacc ctggggaaga gggccccagc ctttgagggc      900

aggatcctgc tcaaccccca ggacaaggat ggctcattca gtgtggtgat cacaggcctg      960

aggaaggagg atgcagggcg ctacctgtgt ggagcccatt cggatggtca gctgcaggaa     1020

ggctcgccta tccaggcctg gcaactcttc gtcaatgagg agtccacgat tccccgcagc     1080

cccactgtgg tgaagggggt ggcaggaggc tctgtggccg tgctctgccc ctacaaccgt     1140

aaggaaagca aaagcatcaa gtactggtgt ctctgggaag gggcccagaa tggccgctgc     1200

cccctgctgg tggacagcga ggggtgggtt aaggcccagt acgagggccg cctctccctg     1260

ctggaggagc caggcaacgg caccttcact gtcatcctca accagctcac cagccgggac     1320

gccggcttct actggtgtct gaccaacggc gatactctct ggaggaccac cgtggagatc     1380

aagattatcg aaggagaacc aaacctcaag gtaccaggga atgtcacggc tgtgctggga     1440

gagactctca aggtcccctg tcactttcca tgcaaattct cctcgtacga gaaatactgg     1500

tgcaagtgga ataacacggg ctgccaggcc ctgcccagcc aagacgaagg ccccagcaag     1560

gccttcgtga actgtgacga gaacagccgg cttgtctccc tgaccctgaa cctggtgacc     1620

agggctgatg agggctggta ctggtgtgga gtgaagcagg gccacttcta tggagagact     1680

gcagccgtct atgtggcagt tgaagagagg aaggcagcgg ggtcccgcga tgtcagccta     1740

gcgaaggcag acgctgctcc tgatgagaag gtgctagact ctggttttcg ggagattgag     1800

aacaaagcca ttcaggatcc caggcttttt gcagaggaaa aggcggtggc agatacaaga     1860

gatcaagccg atgggagcag agcatctgtg gattccggca gctctgagga acaaggtgga     1920

agctccagaa ggtga                                                      1935


<210>  6
<211>  644
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  6

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu Leu Leu Asn Asp Thr Lys Val 
    130                 135                 140                 


Tyr Thr Val Asp Leu Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys 
145                 150                 155                 160 


Thr Glu Asn Ala Gln Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu 
                165                 170                 175     


Tyr Pro Val Leu Val Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr 
            180                 185                 190         


Thr Gly Arg Ile Arg Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe 
        195                 200                 205             


Ser Val Val Ile Asn Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu 
    210                 215                 220                 


Cys Gln Ala Gly Asp Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu 
225                 230                 235                 240 


Gln Val Leu Lys Pro Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly 
                245                 250                 255     


Ser Val Thr Phe His Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala 
            260                 265                 270         


Lys Phe Leu Cys Arg Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val 
        275                 280                 285             


Asn Thr Leu Gly Lys Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu 
    290                 295                 300                 


Asn Pro Gln Asp Lys Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu 
305                 310                 315                 320 


Arg Lys Glu Asp Ala Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly 
                325                 330                 335     


Gln Leu Gln Glu Gly Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn 
            340                 345                 350         


Glu Glu Ser Thr Ile Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala 
        355                 360                 365             


Gly Gly Ser Val Ala Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys 
    370                 375                 380                 


Ser Ile Lys Tyr Trp Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys 
385                 390                 395                 400 


Pro Leu Leu Val Asp Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly 
                405                 410                 415     


Arg Leu Ser Leu Leu Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile 
            420                 425                 430         


Leu Asn Gln Leu Thr Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr 
        435                 440                 445             


Asn Gly Asp Thr Leu Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu 
    450                 455                 460                 


Gly Glu Pro Asn Leu Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly 
465                 470                 475                 480 


Glu Thr Leu Lys Val Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr 
                485                 490                 495     


Glu Lys Tyr Trp Cys Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro 
            500                 505                 510         


Ser Gln Asp Glu Gly Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn 
        515                 520                 525             


Ser Arg Leu Val Ser Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu 
    530                 535                 540                 


Gly Trp Tyr Trp Cys Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr 
545                 550                 555                 560 


Ala Ala Val Tyr Val Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg 
                565                 570                 575     


Asp Val Ser Leu Ala Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu 
            580                 585                 590         


Asp Ser Gly Phe Arg Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg 
        595                 600                 605             


Leu Phe Ala Glu Glu Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp 
    610                 615                 620                 


Gly Ser Arg Ala Ser Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly 
625                 630                 635                 640 


Ser Ser Arg Arg 
                


<210>  7
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  7
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga g               411


<210>  8
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  8

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu 
    130                 135         


<210>  9
<211>  1524
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  9
ctcctaaatg acactaaagt ctacacagtg gacctgggca gaacggtgac catcaactgc       60

cctttcaaga ctgagaatgc tcaaaagagg aagtccttgt acaagcagat aggcctgtac      120

cctgtgctgg tcatcgactc cagtggttat gtaaatccca actatacagg aagaatacgc      180

cttgatattc agggtactgg ccagttactg ttcagcgttg tcatcaacca actcaggctc      240

agcgatgctg ggcagtatct ctgccaggct ggggatgatt ccaatagtaa taagaagaat      300

gctgacctcc aagtgctaaa gcccgagccc gagctggttt atgaagacct gaggggctca      360

gtgaccttcc actgtgccct gggccctgag gtggcaaacg tggccaaatt tctgtgccga      420

cagagcagtg gggaaaactg tgacgtggtc gtcaacaccc tggggaagag ggccccagcc      480

tttgagggca ggatcctgct caacccccag gacaaggatg gctcattcag tgtggtgatc      540

acaggcctga ggaaggagga tgcagggcgc tacctgtgtg gagcccattc ggatggtcag      600

ctgcaggaag gctcgcctat ccaggcctgg caactcttcg tcaatgagga gtccacgatt      660

ccccgcagcc ccactgtggt gaagggggtg gcaggaggct ctgtggccgt gctctgcccc      720

tacaaccgta aggaaagcaa aagcatcaag tactggtgtc tctgggaagg ggcccagaat      780

ggccgctgcc ccctgctggt ggacagcgag gggtgggtta aggcccagta cgagggccgc      840

ctctccctgc tggaggagcc aggcaacggc accttcactg tcatcctcaa ccagctcacc      900

agccgggacg ccggcttcta ctggtgtctg accaacggcg atactctctg gaggaccacc      960

gtggagatca agattatcga aggagaacca aacctcaagg taccagggaa tgtcacggct     1020

gtgctgggag agactctcaa ggtcccctgt cactttccat gcaaattctc ctcgtacgag     1080

aaatactggt gcaagtggaa taacacgggc tgccaggccc tgcccagcca agacgaaggc     1140

cccagcaagg ccttcgtgaa ctgtgacgag aacagccggc ttgtctccct gaccctgaac     1200

ctggtgacca gggctgatga gggctggtac tggtgtggag tgaagcaggg ccacttctat     1260

ggagagactg cagccgtcta tgtggcagtt gaagagagga aggcagcggg gtcccgcgat     1320

gtcagcctag cgaaggcaga cgctgctcct gatgagaagg tgctagactc tggttttcgg     1380

gagattgaga acaaagccat tcaggatccc aggctttttg cagaggaaaa ggcggtggca     1440

gatacaagag atcaagccga tgggagcaga gcatctgtgg attccggcag ctctgaggaa     1500

caaggtggaa gctccagaag gtga                                            1524


<210>  10
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA (R/HpIgR)

<400>  10

Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg Thr Val 
1               5                   10                  15      


Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg Lys Ser 
            20                  25                  30          


Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp Ser Ser 
        35                  40                  45              


Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp Ile Gln 
    50                  55                  60                  


Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu Arg Leu 
65                  70                  75                  80  


Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser Asn Ser 
                85                  90                  95      


Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro Glu Leu 
            100                 105                 110         


Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala Leu Gly 
        115                 120                 125             


Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser Ser Gly 
    130                 135                 140                 


Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala Pro Ala 
145                 150                 155                 160 


Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly Ser Phe 
                165                 170                 175     


Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg Tyr Leu 
            180                 185                 190         


Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro Ile Gln 
        195                 200                 205             


Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg Ser Pro 
    210                 215                 220                 


Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu Cys Pro 
225                 230                 235                 240 


Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu Trp Glu 
                245                 250                 255     


Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu Gly Trp 
            260                 265                 270         


Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu Pro Gly 
        275                 280                 285             


Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg Asp Ala 
    290                 295                 300                 


Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg Thr Thr 
305                 310                 315                 320 


Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val Pro Gly 
                325                 330                 335     


Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys His Phe 
            340                 345                 350         


Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp Asn Asn 
        355                 360                 365             


Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser Lys Ala 
    370                 375                 380                 


Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr Leu Asn 
385                 390                 395                 400 


Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val Lys Gln 
                405                 410                 415     


Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val Glu Glu 
            420                 425                 430         


Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala Asp Ala 
        435                 440                 445             


Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile Glu Asn 
    450                 455                 460                 


Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu Lys Ala Val Ala 
465                 470                 475                 480 


Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser Val Asp Ser Gly 
                485                 490                 495     


Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Arg 
            500                 505         


<210>  11
<211>  2031
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HUMAN pIgR-CD4 cyto (HpIgR-cyto)

<400>  11
atgctgctct tcgtgctcac ctgcctgctg gcggtcttcc cagccatctc cacgaagagt       60

cccatatttg gtcccgagga ggtgaatagt gtggaaggta actcagtgtc catcacgtgc      120

tactacccac ccacctctgt caaccggcac acccggaagt actggtgccg gcagggagct      180

agaggtggct gcataaccct catctcctcg gagggctacg tctccagcaa atatgcaggc      240

agggctaacc tcaccaactt cccggagaac ggcacatttg tggtgaacat tgcccagctg      300

agccaggatg actccgggcg ctacaagtgt ggcctgggca tcaatagccg aggcctgtcc      360

tttgatgtca gcctggaggt cagccagggt cctgggctcc taaatgacac taaagtctac      420

acagtggacc tgggcagaac ggtgaccatc aactgccctt tcaagactga gaatgctcaa      480

aagaggaagt ccttgtacaa gcagataggc ctgtaccctg tgctggtcat cgactccagt      540

ggttatgtaa atcccaacta tacaggaaga atacgccttg atattcaggg tactggccag      600

ttactgttca gcgttgtcat caaccaactc aggctcagcg atgctgggca gtatctctgc      660

caggctgggg atgattccaa tagtaataag aagaatgctg acctccaagt gctaaagccc      720

gagcccgagc tggtttatga agacctgagg ggctcagtga ccttccactg tgccctgggc      780

cctgaggtgg caaacgtggc caaatttctg tgccgacaga gcagtgggga aaactgtgac      840

gtggtcgtca acaccctggg gaagagggcc ccagcctttg agggcaggat cctgctcaac      900

ccccaggaca aggatggctc attcagtgtg gtgatcacag gcctgaggaa ggaggatgca      960

gggcgctacc tgtgtggagc ccattcggat ggtcagctgc aggaaggctc gcctatccag     1020

gcctggcaac tcttcgtcaa tgaggagtcc acgattcccc gcagccccac tgtggtgaag     1080

ggggtggcag gaggctctgt ggccgtgctc tgcccctaca accgtaagga aagcaaaagc     1140

atcaagtact ggtgtctctg ggaaggggcc cagaatggcc gctgccccct gctggtggac     1200

agcgaggggt gggttaaggc ccagtacgag ggccgcctct ccctgctgga ggagccaggc     1260

aacggcacct tcactgtcat cctcaaccag ctcaccagcc gggacgccgg cttctactgg     1320

tgtctgacca acggcgatac tctctggagg accaccgtgg agatcaagat tatcgaagga     1380

gaaccaaacc tcaaggtacc agggaatgtc acggctgtgc tgggagagac tctcaaggtc     1440

ccctgtcact ttccatgcaa attctcctcg tacgagaaat actggtgcaa gtggaataac     1500

acgggctgcc aggccctgcc cagccaagac gaaggcccca gcaaggcctt cgtgaactgt     1560

gacgagaaca gccggcttgt ctccctgacc ctgaacctgg tgaccagggc tgatgagggc     1620

tggtactggt gtggagtgaa gcagggccac ttctatggag agactgcagc cgtctatgtg     1680

gcagttgaag agaggaaggc agcggggtcc cgcgatgtca gcctagcgaa ggcagacgct     1740

gctcctgatg agaaggtgct agactctggt tttcgggaga ttgagaacaa agccattcag     1800

gatcccaggc tttttgcaga ggaaaaggcg gtggcagata caagagatca agccgatggg     1860

agcagagcat ctgtggattc cggcagctct gaggaacaag gtggaagctc cagaaggtgc     1920

cggcaccgaa ggcgccaagc agagcggatg tctcagatca agagactcct cagtgagaag     1980

aagacctgcc agtgccctca ccggtttcag aagacatgta gccccatttg a              2031


<210>  12
<211>  676
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HUMAN pIgR-CD4 cyto (HpIgR-cyto)

<400>  12

Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro Ala Ile 
1               5                   10                  15      


Ser Thr Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu 
            20                  25                  30          


Gly Asn Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn 
        35                  40                  45              


Arg His Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys 
    50                  55                  60                  


Ile Thr Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly 
65                  70                  75                  80  


Arg Ala Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn 
                85                  90                  95      


Ile Ala Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu 
            100                 105                 110         


Gly Ile Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser 
        115                 120                 125             


Gln Gly Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu 
    130                 135                 140                 


Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln 
145                 150                 155                 160 


Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val 
                165                 170                 175     


Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg 
            180                 185                 190         


Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn 
        195                 200                 205             


Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp 
    210                 215                 220                 


Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro 
225                 230                 235                 240 


Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His 
                245                 250                 255     


Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg 
            260                 265                 270         


Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys 
        275                 280                 285             


Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys 
    290                 295                 300                 


Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala 
305                 310                 315                 320 


Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly 
                325                 330                 335     


Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile 
            340                 345                 350         


Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala 
        355                 360                 365             


Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp 
    370                 375                 380                 


Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp 
385                 390                 395                 400 


Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu 
                405                 410                 415     


Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr 
            420                 425                 430         


Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu 
        435                 440                 445             


Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu 
    450                 455                 460                 


Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val 
465                 470                 475                 480 


Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys 
                485                 490                 495     


Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly 
            500                 505                 510         


Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser 
        515                 520                 525             


Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys 
    530                 535                 540                 


Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val 
545                 550                 555                 560 


Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala 
                565                 570                 575     


Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg 
            580                 585                 590         


Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu 
        595                 600                 605             


Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser 
    610                 615                 620                 


Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Arg Cys 
625                 630                 635                 640 


Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu 
                645                 650                 655     


Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr 
            660                 665                 670         


Cys Ser Pro Ile 
        675     


<210>  13
<211>  2058
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RABBIT pIgR-CD4 cyto (RpIgR-cyto)

<400>  13
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga gcctgatgac      420

gttgtttaca aacaatatga gagttataca gtaaccatca cctgcccttt cacatatgcg      480

actaggcaac taaagaagtc cttttacaag gtggaagacg gggaacttgt actcatcatt      540

gattccagca gtaaggaggc aaaggacccc aggtataagg gcagaataac gttgcagatc      600

caaagtacca cagcaaaaga attcacagtc accatcaagc atttgcagct caatgatgct      660

gggcagtatg tctgccagag tggaagcgac cccactgctg aagaacagaa cgttgacctc      720

cgactgctaa ctcctggtct gctctatgga aacctggggg gctcggtgac ctttgaatgt      780

gccctggact ctgaagacgc aaacgcggta gcatccttgc gccaggttag gggtggcaat      840

gtggtcattg acagccaggg gacaatagat ccagccttcg agggcaggat cctgttcacc      900

aaggctgaga acggccactt cagtgtagtg atcgcaggcc tgaggaagga agacacaggg      960

aactatctgt gcggagtcca gtccaatggt cagtctgggg atgggcccac ccagcttcgg     1020

caactcttcg tcaatgaaga gatcgacgtg tcccgcagcc cccctgtgtt gaagggcttt     1080

ccaggaggct ccgtgaccat acgctgcccc tacaacccga agagaagcga cagccacctg     1140

cagctgtatc tctgggaagg gagtcaaacc cgccatctgc tggtggacag cggcgagggg     1200

ctggttcaga aagactacac aggcaggctg gccctgttcg aagagcctgg caatggcacc     1260

ttctcagtcg tcctcaacca gctcactgcc gaggatgaag gcttctactg gtgtgtcagc     1320

gatgacgatg agtccctgac gacttcggtg aagctccaga tcgttgacgg agaaccaagc     1380

cccacgatcg acaagttcac tgctgtgcag ggagagcctg ttgagatcac ctgccacttc     1440

ccatgcaaat acttctcctc cgagaagtac tggtgcaagt ggaatgacca tggctgcgag     1500

gacctgccca ctaagctcag ctccagcggc gaccttgtga aatgcaacaa caacctggtc     1560

ctcaccctga ccttggactc ggtcagcgaa gatgacgagg gctggtactg gtgtggcgcg     1620

aaagacgggc acgagtttga agaggttgcg gccgtcaggg tggagctgac agagccagcc     1680

aaggtagctg tcgagccagc caaggtacct gtcgacccag ccaaggcagc ccccgcgcct     1740

gctgaggaga aggccaaggc gcggtgccca gtgcccagga gaaggcagtg gtacccattg     1800

tcaaggaagc tgagaacaag ttgtccagaa cctcggctcc ttgcggagga ggtagcagtg     1860

cagagtgcgg aagacccagc cagtgggagc agagcgtctg tggatgccag cagtgcttcg     1920

ggacaaagcg ggagtgccaa aaggtgccgg caccgaaggc gccaagcaga gcggatgtct     1980

cagatcaaga gactcctcag tgagaagaag acctgccagt gccctcaccg gtttcagaag     2040

acatgtagcc ccatttga                                                   2058


<210>  14
<211>  685
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RABBIT pIgR-CD4 cyto (RpIgR-cyto)

<400>  14

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu Pro Asp Asp Val Val Tyr Lys 
    130                 135                 140                 


Gln Tyr Glu Ser Tyr Thr Val Thr Ile Thr Cys Pro Phe Thr Tyr Ala 
145                 150                 155                 160 


Thr Arg Gln Leu Lys Lys Ser Phe Tyr Lys Val Glu Asp Gly Glu Leu 
                165                 170                 175     


Val Leu Ile Ile Asp Ser Ser Ser Lys Glu Ala Lys Asp Pro Arg Tyr 
            180                 185                 190         


Lys Gly Arg Ile Thr Leu Gln Ile Gln Ser Thr Thr Ala Lys Glu Phe 
        195                 200                 205             


Thr Val Thr Ile Lys His Leu Gln Leu Asn Asp Ala Gly Gln Tyr Val 
    210                 215                 220                 


Cys Gln Ser Gly Ser Asp Pro Thr Ala Glu Glu Gln Asn Val Asp Leu 
225                 230                 235                 240 


Arg Leu Leu Thr Pro Gly Leu Leu Tyr Gly Asn Leu Gly Gly Ser Val 
                245                 250                 255     


Thr Phe Glu Cys Ala Leu Asp Ser Glu Asp Ala Asn Ala Val Ala Ser 
            260                 265                 270         


Leu Arg Gln Val Arg Gly Gly Asn Val Val Ile Asp Ser Gln Gly Thr 
        275                 280                 285             


Ile Asp Pro Ala Phe Glu Gly Arg Ile Leu Phe Thr Lys Ala Glu Asn 
    290                 295                 300                 


Gly His Phe Ser Val Val Ile Ala Gly Leu Arg Lys Glu Asp Thr Gly 
305                 310                 315                 320 


Asn Tyr Leu Cys Gly Val Gln Ser Asn Gly Gln Ser Gly Asp Gly Pro 
                325                 330                 335     


Thr Gln Leu Arg Gln Leu Phe Val Asn Glu Glu Ile Asp Val Ser Arg 
            340                 345                 350         


Ser Pro Pro Val Leu Lys Gly Phe Pro Gly Gly Ser Val Thr Ile Arg 
        355                 360                 365             


Cys Pro Tyr Asn Pro Lys Arg Ser Asp Ser His Leu Gln Leu Tyr Leu 
    370                 375                 380                 


Trp Glu Gly Ser Gln Thr Arg His Leu Leu Val Asp Ser Gly Glu Gly 
385                 390                 395                 400 


Leu Val Gln Lys Asp Tyr Thr Gly Arg Leu Ala Leu Phe Glu Glu Pro 
                405                 410                 415     


Gly Asn Gly Thr Phe Ser Val Val Leu Asn Gln Leu Thr Ala Glu Asp 
            420                 425                 430         


Glu Gly Phe Tyr Trp Cys Val Ser Asp Asp Asp Glu Ser Leu Thr Thr 
        435                 440                 445             


Ser Val Lys Leu Gln Ile Val Asp Gly Glu Pro Ser Pro Thr Ile Asp 
    450                 455                 460                 


Lys Phe Thr Ala Val Gln Gly Glu Pro Val Glu Ile Thr Cys His Phe 
465                 470                 475                 480 


Pro Cys Lys Tyr Phe Ser Ser Glu Lys Tyr Trp Cys Lys Trp Asn Asp 
                485                 490                 495     


His Gly Cys Glu Asp Leu Pro Thr Lys Leu Ser Ser Ser Gly Asp Leu 
            500                 505                 510         


Val Lys Cys Asn Asn Asn Leu Val Leu Thr Leu Thr Leu Asp Ser Val 
        515                 520                 525             


Ser Glu Asp Asp Glu Gly Trp Tyr Trp Cys Gly Ala Lys Asp Gly His 
    530                 535                 540                 


Glu Phe Glu Glu Val Ala Ala Val Arg Val Glu Leu Thr Glu Pro Ala 
545                 550                 555                 560 


Lys Val Ala Val Glu Pro Ala Lys Val Pro Val Asp Pro Ala Lys Ala 
                565                 570                 575     


Ala Pro Ala Pro Ala Glu Glu Lys Ala Lys Ala Arg Cys Pro Val Pro 
            580                 585                 590         


Arg Arg Arg Gln Trp Tyr Pro Leu Ser Arg Lys Leu Arg Thr Ser Cys 
        595                 600                 605             


Pro Glu Pro Arg Leu Leu Ala Glu Glu Val Ala Val Gln Ser Ala Glu 
    610                 615                 620                 


Asp Pro Ala Ser Gly Ser Arg Ala Ser Val Asp Ala Ser Ser Ala Ser 
625                 630                 635                 640 


Gly Gln Ser Gly Ser Ala Lys Arg Cys Arg His Arg Arg Arg Gln Ala 
                645                 650                 655     


Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys 
            660                 665                 670         


Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        675                 680                 685 


<210>  15
<211>  2046
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  15
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga gctcctaaat      420

gacactaaag tctacacagt ggacctgggc agaacggtga ccatcaactg ccctttcaag      480

actgagaatg ctcaaaagag gaagtccttg tacaagcaga taggcctgta ccctgtgctg      540

gtcatcgact ccagtggtta tgtaaatccc aactatacag gaagaatacg ccttgatatt      600

cagggtactg gccagttact gttcagcgtt gtcatcaacc aactcaggct cagcgatgct      660

gggcagtatc tctgccaggc tggggatgat tccaatagta ataagaagaa tgctgacctc      720

caagtgctaa agcccgagcc cgagctggtt tatgaagacc tgaggggctc agtgaccttc      780

cactgtgccc tgggccctga ggtggcaaac gtggccaaat ttctgtgccg acagagcagt      840

ggggaaaact gtgacgtggt cgtcaacacc ctggggaaga gggccccagc ctttgagggc      900

aggatcctgc tcaaccccca ggacaaggat ggctcattca gtgtggtgat cacaggcctg      960

aggaaggagg atgcagggcg ctacctgtgt ggagcccatt cggatggtca gctgcaggaa     1020

ggctcgccta tccaggcctg gcaactcttc gtcaatgagg agtccacgat tccccgcagc     1080

cccactgtgg tgaagggggt ggcaggaggc tctgtggccg tgctctgccc ctacaaccgt     1140

aaggaaagca aaagcatcaa gtactggtgt ctctgggaag gggcccagaa tggccgctgc     1200

cccctgctgg tggacagcga ggggtgggtt aaggcccagt acgagggccg cctctccctg     1260

ctggaggagc caggcaacgg caccttcact gtcatcctca accagctcac cagccgggac     1320

gccggcttct actggtgtct gaccaacggc gatactctct ggaggaccac cgtggagatc     1380

aagattatcg aaggagaacc aaacctcaag gtaccaggga atgtcacggc tgtgctggga     1440

gagactctca aggtcccctg tcactttcca tgcaaattct cctcgtacga gaaatactgg     1500

tgcaagtgga ataacacggg ctgccaggcc ctgcccagcc aagacgaagg ccccagcaag     1560

gccttcgtga actgtgacga gaacagccgg cttgtctccc tgaccctgaa cctggtgacc     1620

agggctgatg agggctggta ctggtgtgga gtgaagcagg gccacttcta tggagagact     1680

gcagccgtct atgtggcagt tgaagagagg aaggcagcgg ggtcccgcga tgtcagccta     1740

gcgaaggcag acgctgctcc tgatgagaag gtgctagact ctggttttcg ggagattgag     1800

aacaaagcca ttcaggatcc caggcttttt gcagaggaaa aggcggtggc agatacaaga     1860

gatcaagccg atgggagcag agcatctgtg gattccggca gctctgagga acaaggtgga     1920

agctccagaa ggtgccggca ccgaaggcgc caagcagagc ggatgtctca gatcaagaga     1980

ctcctcagtg agaagaagac ctgccagtgc cctcaccggt ttcagaagac atgtagcccc     2040

atttga                                                                2046


<210>  16
<211>  681
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  16

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu Leu Leu Asn Asp Thr Lys Val 
    130                 135                 140                 


Tyr Thr Val Asp Leu Gly Arg Thr Val Thr Ile Asn Cys Pro Phe Lys 
145                 150                 155                 160 


Thr Glu Asn Ala Gln Lys Arg Lys Ser Leu Tyr Lys Gln Ile Gly Leu 
                165                 170                 175     


Tyr Pro Val Leu Val Ile Asp Ser Ser Gly Tyr Val Asn Pro Asn Tyr 
            180                 185                 190         


Thr Gly Arg Ile Arg Leu Asp Ile Gln Gly Thr Gly Gln Leu Leu Phe 
        195                 200                 205             


Ser Val Val Ile Asn Gln Leu Arg Leu Ser Asp Ala Gly Gln Tyr Leu 
    210                 215                 220                 


Cys Gln Ala Gly Asp Asp Ser Asn Ser Asn Lys Lys Asn Ala Asp Leu 
225                 230                 235                 240 


Gln Val Leu Lys Pro Glu Pro Glu Leu Val Tyr Glu Asp Leu Arg Gly 
                245                 250                 255     


Ser Val Thr Phe His Cys Ala Leu Gly Pro Glu Val Ala Asn Val Ala 
            260                 265                 270         


Lys Phe Leu Cys Arg Gln Ser Ser Gly Glu Asn Cys Asp Val Val Val 
        275                 280                 285             


Asn Thr Leu Gly Lys Arg Ala Pro Ala Phe Glu Gly Arg Ile Leu Leu 
    290                 295                 300                 


Asn Pro Gln Asp Lys Asp Gly Ser Phe Ser Val Val Ile Thr Gly Leu 
305                 310                 315                 320 


Arg Lys Glu Asp Ala Gly Arg Tyr Leu Cys Gly Ala His Ser Asp Gly 
                325                 330                 335     


Gln Leu Gln Glu Gly Ser Pro Ile Gln Ala Trp Gln Leu Phe Val Asn 
            340                 345                 350         


Glu Glu Ser Thr Ile Pro Arg Ser Pro Thr Val Val Lys Gly Val Ala 
        355                 360                 365             


Gly Gly Ser Val Ala Val Leu Cys Pro Tyr Asn Arg Lys Glu Ser Lys 
    370                 375                 380                 


Ser Ile Lys Tyr Trp Cys Leu Trp Glu Gly Ala Gln Asn Gly Arg Cys 
385                 390                 395                 400 


Pro Leu Leu Val Asp Ser Glu Gly Trp Val Lys Ala Gln Tyr Glu Gly 
                405                 410                 415     


Arg Leu Ser Leu Leu Glu Glu Pro Gly Asn Gly Thr Phe Thr Val Ile 
            420                 425                 430         


Leu Asn Gln Leu Thr Ser Arg Asp Ala Gly Phe Tyr Trp Cys Leu Thr 
        435                 440                 445             


Asn Gly Asp Thr Leu Trp Arg Thr Thr Val Glu Ile Lys Ile Ile Glu 
    450                 455                 460                 


Gly Glu Pro Asn Leu Lys Val Pro Gly Asn Val Thr Ala Val Leu Gly 
465                 470                 475                 480 


Glu Thr Leu Lys Val Pro Cys His Phe Pro Cys Lys Phe Ser Ser Tyr 
                485                 490                 495     


Glu Lys Tyr Trp Cys Lys Trp Asn Asn Thr Gly Cys Gln Ala Leu Pro 
            500                 505                 510         


Ser Gln Asp Glu Gly Pro Ser Lys Ala Phe Val Asn Cys Asp Glu Asn 
        515                 520                 525             


Ser Arg Leu Val Ser Leu Thr Leu Asn Leu Val Thr Arg Ala Asp Glu 
    530                 535                 540                 


Gly Trp Tyr Trp Cys Gly Val Lys Gln Gly His Phe Tyr Gly Glu Thr 
545                 550                 555                 560 


Ala Ala Val Tyr Val Ala Val Glu Glu Arg Lys Ala Ala Gly Ser Arg 
                565                 570                 575     


Asp Val Ser Leu Ala Lys Ala Asp Ala Ala Pro Asp Glu Lys Val Leu 
            580                 585                 590         


Asp Ser Gly Phe Arg Glu Ile Glu Asn Lys Ala Ile Gln Asp Pro Arg 
        595                 600                 605             


Leu Phe Ala Glu Glu Lys Ala Val Ala Asp Thr Arg Asp Gln Ala Asp 
    610                 615                 620                 


Gly Ser Arg Ala Ser Val Asp Ser Gly Ser Ser Glu Glu Gln Gly Gly 
625                 630                 635                 640 


Ser Ser Arg Arg Cys Arg His Arg Arg Arg Gln Ala Glu Arg Met Ser 
                645                 650                 655     


Gln Ile Lys Arg Leu Leu Ser Glu Lys Lys Thr Cys Gln Cys Pro His 
            660                 665                 670         


Arg Phe Gln Lys Thr Cys Ser Pro Ile 
        675                 680     


<210>  17
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  17
atggctctct tcttgctcac ctgcctgctg gctgtctttt cagcggccac ggcacaaagc       60

tccttattgg gtcccagctc catatttggt cccggggagg tgaatgtttt ggaaggcgac      120

tcggtgtcca tcacatgcta ctacccaaca acctccgtca cccggcacag ccggaagttc      180

tggtgccggg aagaggagag cggccgctgc gtgacgcttg cctcgaccgg ctacacgtcc      240

caggaatact ccgggagagg caagctcacc gacttccctg ataaagggga gtttgtggtg      300

actgttgacc aactcaccca gaacgactca gggagctaca agtgtggcgt gggagtcaac      360

ggccgtggcc tggacttcgg tgtcaacgtg ctggtcagcc agaagccaga g               411


<210>  18
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  18

Met Ala Leu Phe Leu Leu Thr Cys Leu Leu Ala Val Phe Ser Ala Ala 
1               5                   10                  15      


Thr Ala Gln Ser Ser Leu Leu Gly Pro Ser Ser Ile Phe Gly Pro Gly 
            20                  25                  30          


Glu Val Asn Val Leu Glu Gly Asp Ser Val Ser Ile Thr Cys Tyr Tyr 
        35                  40                  45              


Pro Thr Thr Ser Val Thr Arg His Ser Arg Lys Phe Trp Cys Arg Glu 
    50                  55                  60                  


Glu Glu Ser Gly Arg Cys Val Thr Leu Ala Ser Thr Gly Tyr Thr Ser 
65                  70                  75                  80  


Gln Glu Tyr Ser Gly Arg Gly Lys Leu Thr Asp Phe Pro Asp Lys Gly 
                85                  90                  95      


Glu Phe Val Val Thr Val Asp Gln Leu Thr Gln Asn Asp Ser Gly Ser 
            100                 105                 110         


Tyr Lys Cys Gly Val Gly Val Asn Gly Arg Gly Leu Asp Phe Gly Val 
        115                 120                 125             


Asn Val Leu Val Ser Gln Lys Pro Glu 
    130                 135         


<210>  19
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  19
ctcctaaatg acactaaagt ctacacagtg gacctgggca gaacggtgac catcaactgc       60

cctttcaaga ctgagaatgc tcaaaagagg aagtccttgt acaagcagat aggcctgtac      120

cctgtgctgg tcatcgactc cagtggttat gtaaatccca actatacagg aagaatacgc      180

cttgatattc agggtactgg ccagttactg ttcagcgttg tcatcaacca actcaggctc      240

agcgatgctg ggcagtatct ctgccaggct ggggatgatt ccaatagtaa taagaagaat      300

gctgacctcc aagtgctaaa gcccgagccc gagctggttt atgaagacct gaggggctca      360

gtgaccttcc actgtgccct gggccctgag gtggcaaacg tggccaaatt tctgtgccga      420

cagagcagtg gggaaaactg tgacgtggtc gtcaacaccc tggggaagag ggccccagcc      480

tttgagggca ggatcctgct caacccccag gacaaggatg gctcattcag tgtggtgatc      540

acaggcctga ggaaggagga tgcagggcgc tacctgtgtg gagcccattc ggatggtcag      600

ctgcaggaag gctcgcctat ccaggcctgg caactcttcg tcaatgagga gtccacgatt      660

ccccgcagcc ccactgtggt gaagggggtg gcaggaggct ctgtggccgt gctctgcccc      720

tacaaccgta aggaaagcaa aagcatcaag tactggtgtc tctgggaagg ggcccagaat      780

ggccgctgcc ccctgctggt ggacagcgag gggtgggtta aggcccagta cgagggccgc      840

ctctccctgc tggaggagcc aggcaacggc accttcactg tcatcctcaa ccagctcacc      900

agccgggacg ccggcttcta ctggtgtctg accaacggcg atactctctg gaggaccacc      960

gtggagatca agattatcga aggagaacca aacctcaagg taccagggaa tgtcacggct     1020

gtgctgggag agactctcaa ggtcccctgt cactttccat gcaaattctc ctcgtacgag     1080

aaatactggt gcaagtggaa taacacgggc tgccaggccc tgcccagcca agacgaaggc     1140

cccagcaagg ccttcgtgaa ctgtgacgag aacagccggc ttgtctccct gaccctgaac     1200

ctggtgacca gggctgatga gggctggtac tggtgtggag tgaagcaggg ccacttctat     1260

ggagagactg cagccgtcta tgtggcagtt gaagagagga aggcagcggg gtcccgcgat     1320

gtcagcctag cgaaggcaga cgctgctcct gatgagaagg tgctagactc tggttttcgg     1380

gagattgaga acaaagccat tcaggatccc aggctttttg cagaggaaaa ggcggtggca     1440

gatacaagag atcaagccga tgggagcaga gcatctgtgg attccggcag ctctgaggaa     1500

caaggtggaa gctccagaag gtgccggcac cgaaggcgcc aagcagagcg gatgtctcag     1560

atcaagagac tcctcagtga gaagaagacc tgccagtgcc ctcaccggtt tcagaagaca     1620

tgtagcccca tttga                                                      1635


<210>  20
<211>  544
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHIMERA-CD4 cyto (R/HpIgR-cyto)

<400>  20

Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg Thr Val 
1               5                   10                  15      


Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg Lys Ser 
            20                  25                  30          


Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp Ser Ser 
        35                  40                  45              


Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp Ile Gln 
    50                  55                  60                  


Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu Arg Leu 
65                  70                  75                  80  


Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser Asn Ser 
                85                  90                  95      


Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro Glu Leu 
            100                 105                 110         


Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala Leu Gly 
        115                 120                 125             


Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser Ser Gly 
    130                 135                 140                 


Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala Pro Ala 
145                 150                 155                 160 


Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly Ser Phe 
                165                 170                 175     


Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg Tyr Leu 
            180                 185                 190         


Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro Ile Gln 
        195                 200                 205             


Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg Ser Pro 
    210                 215                 220                 


Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu Cys Pro 
225                 230                 235                 240 


Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu Trp Glu 
                245                 250                 255     


Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu Gly Trp 
            260                 265                 270         


Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu Pro Gly 
        275                 280                 285             


Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg Asp Ala 
    290                 295                 300                 


Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg Thr Thr 
305                 310                 315                 320 


Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val Pro Gly 
                325                 330                 335     


Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys His Phe 
            340                 345                 350         


Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp Asn Asn 
        355                 360                 365             


Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser Lys Ala 
    370                 375                 380                 


Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr Leu Asn 
385                 390                 395                 400 


Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val Lys Gln 
                405                 410                 415     


Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val Glu Glu 
            420                 425                 430         


Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala Asp Ala 
        435                 440                 445             


Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile Glu Asn 
    450                 455                 460                 


Lys Ala Ile Gln Asp Pro Arg Leu Phe Ala Glu Glu Lys Ala Val Ala 
465                 470                 475                 480 


Asp Thr Arg Asp Gln Ala Asp Gly Ser Arg Ala Ser Val Asp Ser Gly 
                485                 490                 495     


Ser Ser Glu Glu Gln Gly Gly Ser Ser Arg Arg Cys Arg His Arg Arg 
            500                 505                 510         


Arg Gln Ala Glu Arg Met Ser Gln Ile Lys Arg Leu Leu Ser Glu Lys 
        515                 520                 525             


Lys Thr Cys Gln Cys Pro His Arg Phe Gln Lys Thr Cys Ser Pro Ile 
    530                 535                 540                 


